NFL NBA Megan Anderson Atlanta Hawks Los Angeles Lakers Boston Celtics Arsenal F. C. Philadelphia 76ers Premier League UFC. Project Slayers codes list. There's been times where I've thought "it's good flavour but it's not the best" then there's been times where I've thought, "this flavour is incredible, it's one of the best". So, first, on obesity, you've noted inherent uncertainty. Smok Novo 2 Pod Lifespan. Operator instructions] I would now like to turn the conference over to your speaker today, Lars Fruergaard Jorgensen, CEO. Richard Vosser -- JPMorgan Chase and Company -- Analyst. And then, it's, in the U. S., up to Doug and his team to discuss with payers and others on how that will impact the dynamics. We expect the financial items will amount to a net gain of around 2. Open the Settings app. Our reported sales are expected to be 4 percentage points lower at CER, and operating profit is expected to be 5 percentage points lower at CER. And then, as to the pipeline, I'd say there are two main drivers to step-up. Why is my novo 2 not hitting. So, capex, of course, quite a significant step-up compared at our capital markets day.
Improved protein structure prediction. Thank you for taking my questions. That's right -- they think these 10 stocks are even better buys. Finally, we expect to initiate a phase 3b trial of Ziltivekimab for the treatment of heart failure with preserved ejection fraction in the first half of 2023. That is when we start to come down on future market growth rates. Overall, 80% access is something that we're proud of, and the team has done a nice job. Why is my novo 2 blinking. Smok Novo 2S Battery Section. And from an NBRx perspective, we continue to see all-time high levels of new patients starting on our portfolio of GLP-1 products by the end of 2022. It comes from the line of Sachin Jain from Bank of America. So, that's why we're looking at also expanding our capacity on the monoclonal antibody sides. 2 x Novo 2 Clear pods (MESHED 0. Powered Tools Not Named ChatGPT. So, any crystal ball now? Two very clear questions.
So, I hope that provides a little bit of color, but not fully able to separate the hot and the cold water. Raw audio is never collected or stored for the purposes of Crash Detection or to improve Crash Detection. And then, to Lars and Karsten, just if I could try my luck and push you to better understand what is possible and what is not. Is A.I. Drug Discovery and Biotech Hitting Promised Lands yet in 2023. After the first time, it plays at a reduced volume, so that you or someone nearby can talk on the call to the emergency responder. Rare blood disorders grew by 7%, driven by NovoSeven, as well as the launch product, Esperoct and Refixia. But they look at everything, and they can recommend to stop the trials should they fail to do so. We're still investing in insulin and think we can drive tremendous value for patients and physicians here, still, 100 years in.
That means we have improved our market share by 1. And it comes in the line of Michael Nedelcovych from Cowen. Now let's get into today's topic: I've been really into some of the biotech news coming out of A. drug discovery: I really like covering A. startups at the intersection of computational biology, biotech, genomics, and drug development. And then, Karsten, you can get to the GLP-1. How Crash Detection on your iPhone and Apple Watch works. There is also a small hole which is for the draw activation sensor. While the GLP-1 class growth is more than 50%, GLP-1 penetration remains low at around 5% of total diabetes groups globally. Why is my smok novo 2 not hitting. No of course not, for example the lack of a power button means if you have young children you need to make sure it's always out of reach. The secret is in the "non-coding" regions of RNA, which are like the header and footer on a document. 🌍 Newsletter updates, milestones, polls and more. Just from your perspective, are you expecting a trend shift through full year '23 from the existing 40% to 50% growth? The sales growth within diabetes and obesity care is expected to be partially countered by declining sales in rare disease due to supply constraints. And I think there's been commentary on pent-up demand and cash with the first data points. My Talent Collective.
And next slide, please. At the annual general meeting on March 23, 2023, the board of directors will propose a final dividend of 8. 2023 is truly a significant year in history of Novo Nordisk as we celebrate our 100-year anniversary. It comes from the line of Richard Parkes from BNP Paribas. The effective tax rate in '22 was 19.
You can add that to DPP-4 price decline, and soon to come, SGLT2, will also create some space to fund innovation.